Tim Wehr is staff scientist at Bio-Rad Laboratories, Hercules, California. Direct correspondence about this column to Direct correspondence about this column to Directions in Discovery, LCGC, Woodbridge Corporate Plaza, 485 Route 1 South, Building F, First Floor, Iselin, NJ 08830, e-mail lcgcedit@lcgcmag.com.
 | September 1, 2009
By:Tim Wehr
A multilaboratory collaborative study organized by the Human Proteome Organization demonstrated that participating laboratories had difficulty in identifying components of a simple protein mixture.
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 | July 1, 2009
By:Tim Wehr
Following the sequencing of the human genome, the biological science community has moved to tackle the human proteome.
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 | March 1, 2009
By:Tim Wehr
ERLIC is a new technique that shows promise as an alternative or complementary technique for both enrichment and separation of these posttranslationally-modified peptides.
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 | September 1, 2008
By:Tim Wehr
A number of commercial in-solution, and in-gel IEF fractionation systems are described in this month's column.
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 | June 1, 2008
By:Tim Wehr
This installment of "Directions in Discovery" will review current phosphorylation enrichment techniques with a focus on new developments.
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 | March 1, 2008
By:Tim Wehr
In the last year, two new protein depletion products have been introduced, and these will be the focus of this month's installment of "Directions in Discovery."
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October 1, 2007
By:Tim Wehr
Quantitative assessment of protein expression in biological systems in response to perturbations is an important element in the discovery and validation of biomarkers and drug targets. This can be a challenging task given the complexity and dynamic range of biological extracts. Many methods are currently in use to address protein quantification. This installment of "Directions in Discovery" reviews several of the more popular ones and reports on a collaborative study organized by the Association of Biomolecular Resource Facilities.
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 | March 1, 2007
By:Klara Valko
Fast, reliable measurements of lipophilicity has a great impact on the compounds' selection process at an early stage of dug discovery. The guest columnit examines HPLC methods for this purpose.
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September 1, 2006
By:Tim Wehr
Top-down and bottom-up are alternative strategies for protein identification and characterization by mass spectrometry. How do they fit into the world of proteomics? What are their implications for separation technology? These questions are addressed in this installment of "Directions in Discovery."
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