LC Troubleshooting sets about making HPLC methods easier to master. By covering the basics of liquid chromatography separations and instrumentation, columnist John Dolan is able to highlight common problems and provide remedies for them.
 | December 1, 2009
By:John W. Dolan
John Dolan looks at ways to get to the root of some of the most common problems encountered in the lab.
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 | August 1, 2010
By:John W. Dolan
Deterioration of the separation can result from many causes. This month's column looks at some techniques to isolate the problem source.
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 | July 1, 2010
By:John W. Dolan
John Dolan looks at a case in which the peak doesn't seem to belong with the neighboring peaks in the chromatogram.
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 | July 1, 2010
By:John W. Dolan
A broad peak where it doesn't belong is a classic sign of late elution.
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June 1, 2010
By:John W. Dolan
This is John Dolan's 300th "LC Troubleshooting" column. Here, he takes a look through the archives.
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 | June 1, 2010
By:John W. Dolan
John Dolan reaches a milestone with his 300th installment of "LC Troubleshooting" and takes a look back through the years.
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May 1, 2010
By:John W. Dolan
Look at the big picture. It may not be appropriate to obsess on the details
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 | May 1, 2010
By:John W. Dolan
In recent conversations at Pittcon 2010, it became clear to the author that sometimes we get too focused on the details of the method without backing up and determining how the fit into the big picture.
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