Column: LC Troubleshooting - Chromatography Online
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Column: LC Troubleshooting
LC Troubleshooting sets about making HPLC methods easier to master. By covering the basics of liquid chromatography separations and instrumentation, columnist John Dolan is able to highlight common problems and provide remedies for them.

LC Troubleshooting Strategies

December 1, 2009

John Dolan looks at ways to get to the root of some of the most common problems encountered in the lab.

Speeding Up Gradients

September 1, 2010

How to make gradient separations faster without changing the separation

System Contamination

August 1, 2010

Deterioration of the separation can result from many causes. This month's column looks at some techniques to isolate the problem source.

Where Did That Peak Come From?

July 1, 2010

John Dolan looks at a case in which the peak doesn't seem to belong with the neighboring peaks in the chromatogram.

Where Did That Peak Come From?

July 1, 2010

A broad peak where it doesn't belong is a classic sign of late elution.

300 and Counting

June 1, 2010

This is John Dolan's 300th "LC Troubleshooting" column. Here, he takes a look through the archives.

300 and Counting

June 1, 2010

John Dolan reaches a milestone with his 300th installment of "LC Troubleshooting" and takes a look back through the years.

Too Much Scrutiny

May 1, 2010

Look at the big picture. It may not be appropriate to obsess on the details

Too Much Scrutiny

May 1, 2010

In recent conversations at Pittcon 2010, it became clear to the author that sometimes we get too focused on the details of the method without backing up and determining how the fit into the big picture.

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