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Articles by John W. Dolan

John W. Dolan

"LC Troubleshooting" Editor

John Dolan has been writing "LC Troubleshooting" for LCGC for over 20 years. One of the industry's most respected professionals, John is currently the Vice President of BASi Northwest Laboratory, McMinnville, Oregon and a principal instructor for LC Resources, Walnut Creek, California. He is also a member of LCGC's editorial advisory board.

Articles
Calibration Curves, Part IV: Choosing the Appropriate Model
June 1, 2009

Part IV of this series focuses on three different calibration models: external standardization, internal standardization, and the method of standard additions.

Calibration Curves III: A Different View
May 1, 2009

This is the third installment in a series of LC Troubleshooting columns that focus on calibration curves used for LC methods. Here, John Dolan considers some alternate ways to look at the data to determine if they appear to be normal or are trying to tell us something is amiss.

Calibration Curves, Part II: What are the Limits?
April 1, 2009

In part two of this series, John Dolan looks at the signal-to-noise ratio and its relationship to uncertainty in a measurement.

Calibration Curves, Part I: To b or Not to b?
March 1, 2009

This month's "LC Troubleshooting" looks at some different calibration models, how to decide if a calibration curve goes through zero, and some problems that can occur if the wrong choices are made.

Testing Method Performance
February 1, 2009

This month's "LC Troubleshooting" discussion will center on the recommendations of the CDER document, especially in terms of what it means from a practical method performance standpoint.

Problems from East and West
January 1, 2009

At the beginning of the year, it is good to look back in time- are there things that we can learn from the past? After a series of troubleshooting and method development seminars in Istanbul, Turkey, and Amman, Jordan, John Dolan looks back.

LC Pumps
December 1, 2008

This month's "LC Troubleshooting" installment will take a look at the design of these durable pumps and also examine some of the potential weaknesses and how to overcome them.

Extracolumn Effects
November 1, 2008

All the buzz lately about LC columns packed with particles smaller than 3 mm often comes with warnings about extracolumn effects. This month's installment will take a look at what these effects are and more.

Drip, Drip, Drip . . .
October 1, 2008

This "LC Troubleshooting" installment marks the beginning of the 26th year that John Dolan has written this column.

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