John W. Dolan

John Dolan has been writing "LC Troubleshooting" for LCGC for over 20 years. One of the industry's most respected professionals, John is currently the Vice President of BASi Northwest Laboratory, McMinnville, Oregon and a principal instructor for LC Resources, Walnut Creek, California. He is also a member of LCGC's editorial advisory board.

What's the best way to integrate a peak?

This month's column discusses the type of problems one can encounter when using methods supplied to us by other.

Remember the Rule of One — change just one thing at a time

This is the fifth and final installment in a series of columns about various aspects of calibration of LC methods.

Part IV of this series focuses on three different calibration models: external standardization, internal standardization, and the method of standard additions.

This is the third installment in a series of LC Troubleshooting columns that focus on calibration curves used for LC methods. Here, John Dolan considers some alternate ways to look at the data to determine if they appear to be normal or are trying to tell us something is amiss.

In part two of this series, John Dolan looks at the signal-to-noise ratio and its relationship to uncertainty in a measurement.

This month's "LC Troubleshooting" looks at some different calibration models, how to decide if a calibration curve goes through zero, and some problems that can occur if the wrong choices are made.

This month's "LC Troubleshooting" discussion will center on the recommendations of the CDER document, especially in terms of what it means from a practical method performance standpoint.