Various modes of capillary electrochromatography (CEC) for the separation of enantiomers on immobilized cyclodextrin derivatives are described. The following techniques have been used: (i) open-tubular electrochromatography (o-CEC), (ii) packed electrochromatography (p-CEC) and (iii) monolithic electrochromatography (rod-CEC). Three different strategies to prepare enantioselective cyclodextrin-coated chiral monoliths are described. The advantages and disadvantages of the various methods are outlined.
Feb 1, 2009
By:Dorothee Witsuba, Volker Schurig
Various modes of capillary electrochromatography (CEC) for the separation of enantiomers on immobilized cyclodextrin derivatives are described. The following techniques have been used: (i) open-tubular electrochromatography (o-CEC), (ii) packed electrochromatography (p-CEC) and (iii) monolithic electrochromatography (rod-CEC). Three different strategies to prepare enantioselective cyclodextrin-coated chiral monoliths are described. The advantages and disadvantages of the various methods are outlined.
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Sep 1, 2008
The move from conventional particle sizes (5 μm or higher) to smaller diameter packing materials is one of the most attractive approaches to achieve higher separating efficiency. Recently developed 3 μm polysaccharide-derived chiral stationary phases demonstrate characteristics of favourable mass transfer kinetics, high column efficiency and good column permeability. This allows the fast analysis of enantiomers using conventional HPLC instruments.
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Jul 7, 2008
Professor Wolfgang Lindner from the Department of Analytical Chemistry and Food Chemistry at the University of Vienna, Austria, has been awarded the 2008 Chirality Medal in recognition of his achievements in the field of separation sciences and in particular stereoselective separation techniques.
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Jun 25, 2008
Chiral Technologies Europe offers a flexible custom separation service for preparative separation and purification of pharmaceutical lead compounds and intermediates.
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Jun 23, 2008
Application note
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Jun 23, 2008
Application note
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Jun 1, 2008
20th International Symposium on Chirality ISCD-20 2008, Geneva Switzerland
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May 1, 2008
The Chirality Medal was instituted by the Societa Chimica Italiana in 1991 and honours internationally recognized scientists who have made a distinguished contribution to all aspects of chirality.
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Jan 16, 2008
SFC PicLab Analytic
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