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Icons of Chromatography: Harold McNair


LCGC Europe
Volume 22, Issue 10

Who introduced you to GC?



Dr A.J.P. Martin, Dr Steve Dal Nogare and Prof. A.I.M. Keulemans. You could not have wished for a better group of mentors. In 1957, I performed my first GC injections. I was a graduate student at Purdue University and had just finished a Masters in electrochemistry. I wanted an exciting new topic for my PhD work. I took a summer job at Amoco's Research Labs in Whiting, Indiana, USA. My job was to screen around 80 new liquid phases for selectivity to separate butane-1 and iso-butylene as well as some C18 unsaturated methyl esters. During the summer job, Nobel Laureate A.J.P. Martin came to the labs to install his new gas density balance detector.

I was assigned as his "gofor" for the day. It was a memorable experience; he really turned me on to GC with his knowledge and enthusiasm and tips on making tea (heat the cup!). The next summer, I worked with Steve Dal Nogare from DuPont in Wilmington, Delaware, USA and was indoctrinated in temperature-programmed GC. Steve was a great mentor and very enthusiastic about GC. Finally, my Fulbright fellowship with Professor A.I.M. Keulemans in 1959, convinced me I would work on GC for as long as I could. So many of the pioneers in GC came to his lab and I was fortunate to work with many of them — and this fired my enthusiasm for GC.

What do you see as your greatest achievement in the field?



My greatest achievement is collaborating with my students — undergraduates, graduates, post-doctoral fellows — and visiting professors (easily over 200 total). This group of intelligent, humorous, hard-working people made my research and teaching both interesting and challenging — most of the time! It would be unfair to mention any single individual as there were too many major breakthroughs from a wide range of people. Highlights would definitely include reporting the first capillary GC–MS results in 1961; introducing temperature programmed LC in 1981; using mobile phase modifiers to stabilize retention times on silica gel; developing the first directly coupled LC/GC experiment using two independent computers in 1981; identifying the role of pH in CZE to add to the electrostatic mobility of highly hydrated protons: and also early work on analysing steroids in urine by GC-TOF-MS. The latter study was one of the earliest demonstrations of the use of TOF-MS coupled to GC for determining traces of steroids in urine and this work was honoured with an "outstanding Ph.D. thesis award" from Virginia Tech.

A research project in 1976, which correlated pKb's of weak aromatic amines with retention time on acidic silica gel, was recognized by NASA as the second most cited scientific publication for that year. The Viking-Mars Landing was Number One! Our work was one of the first publications on the LC analysis of aromatic diamines. Not only did this class of compounds hold high interest for NASA in relation to polymer research, but they also held high biological significance; thus, many researchers in the biomedical and pharmaceutical communities also paid close attention to this work.

But equally as important as the quality of the scientific publications was the work ethic, the group effort and strong friendships established while at Virginia Tech. Some of the best memories were the long van rides to Pittcon each year. I was always so proud when one of my students gave a great lecture at some conference. I am still in contact with almost all of my former students.


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