Detection of Doping Agents by LC–MS and LC–MS-MS

In the last decade, research on the detection of all groups of doping agents has been investigated by LC-MS, and routine LC-MS screening applications are now available for almost all classes of doping agents.

Techniques for Structure Elucidation of Unknowns: Finding Substitute Active Pharmaceutical Ingredients in Counterfeit Medicines

This month's column brings much of the previous discussion on how to interpret mass spectra to a practical examination of detecting substitutions in counterfeit pharmaceuticals.

Alternatives in the Face of Chemical Diversity

In this month's "MS-The Practical Art," Michael Balogh takes a closer look at insight provided by Chuck McEwen regarding obstacles while using solvents.

High-Throughput Quantitative LC-MS-MS Assays by On-Line Extraction Using Monolithic Support

LC-MS-MS has become a widely used technique for the fast and sensitive quantitation of small molecules. In this article, this approach has been extended to high-throughput quantitative LC-MS-MS analysis under GLP applications for a drug candidate in development from preclinical animal studies through clinical development.

How Little Feb 07

The future Feb 07

The Expanding Role of LC–ICP-MS Speciation Analysis in the Life Sciences: Element- Selective Screening and Species-Independent Quantification

Emerging as a complementary analytical tool to LC-MS, LC-ICP-MS brings added value to the determination of inorganic element containing molecules of biological importance.

The Expanding 1/07

Ionization Revisited

Over the last ten years or so, information gathered by applying atmospheric ionization techniques in mass spectrometry teaches us two things: 1) that liquid is a vestigial remnant of condensed-phase liquid chromatography and 2) that solvent in the gas phase limits ionization to molecules that are more basic than the solvent.