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Size-exclusion chromatography

Identifying Differences in Solution Conformations of Two Chimeric IgG3 Antibodies through Triple Detection SEC

January 1, 2006
By:Emma Longman, Stephen E. Harding, Nicola Marheineke

Size exclusion chromatography (SEC) coupled to light-scattering, viscometer and refractive index detectors is a common technique used for the characterization of polymers. In this article the solution conformations of two chimeric IgG3 antibodies were studied using this coupled triple detection technique. Conclusions indicate that the results allow hydrodynamic modeling of the antibody structures.

A Laser Diode Double-Pumped Solid-State Laser-Induced Fluorescence Detector for Capillary Electrophoresis and Liquid Chromatography

October 1, 2005
By:Bingcheng Yang, Feng Tan, Yafeng Guan

The authors describe a new laser-induced flourescence detector for application to both capillary electrophoresis (CE) and high-performance liquid chromatography (HPLC).

A High-Volume, High-Throughput LC–MS Therapeutic Drug Monitoring System

April 1, 2005
By:Kolbjorn Zahlsen, Trond Aamo, Jerry Zweigenbaum

LC-MS monitoring of the drug clozapine is detailed along with a description of the overall system architecture, workflow, and maintenance routines that spport a large-scale drug monitoring program.

Control of Matrix Effects in Bioanalytical MS–MS Using On-line Multidimensional Solid-Phase Extraction

April 1, 2005
By:Katrin Georgi, Karl-Siegfried Boos

The authors discuss a solid-phase extraction (SPE) clean-up procedure for drugs present in biofluids.

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